Lyophilization Cycle Development

Demo

Design and optimize freeze-drying cycles with heat-transfer modeling, sublimation rate estimation, and interactive cycle visualization. Adjust parameters and see real-time impact on cycle time and collapse risk.

Product & Vial

Fill Volume (mL)

Vial Diameter (cm)

Collapse Temp (Tc) (°C)

Freezing

Cooling Rate (°C/min)

Min Temp (°C)

Hold Time (min)

Primary Drying

Shelf Temp (°C)

Chamber Pressure (mTorr)

Target Product Temp (°C)

Secondary Drying

Ramp Rate (°C/min)

Final Temp (°C)

Hold Time (min)

Total Cycle

64.8 hr

Sublimation Rate

53.8 mg/hr

9 W/(m²·K)

Collapse Margin

15 °C

Lyophilization Cycle Profile

Shelf temperature and chamber pressure over time

Phase Breakdown

Freezing Ramp1.1 hr

1.7%

Freezing Hold2.0 hr

3.1%

Primary Ramp25 min

0.6%

Primary Drying51.2 hr

78.9%

Secondary Ramp4.2 hr

6.4%

Secondary Hold6.0 hr

9.3%

Total64.8 hr (3,890 min)